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[14] One of the main modulators of its activity is the cytosolic NADP + /NADPH ratio

This finding shows that all three domains of SOCS2 (N-terminal ESS, SH2, and SOCS box) can undergo conformational changes and work together to channel their substrates to ubiquitin-mediated degradation

As discussed previously, NO synthesis is likely increased during at least some stages of chronic sleep restriction, pointing to NO as one possible mediator linking sleep disturbance to neurodegenerative pathology

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Grids were then stained with 1% phosphotungstic acid for 1 min, and the excess solution was cleared